PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis

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成果类型：

期刊论文

作者：

Li, Chao;Li, Shang-Ze;Huang, Xi-Cheng;Chen, Jie;Liu, Wenbin;...

通讯作者：

Du, R.-L.;Song, X.-M.

作者机构：

[Li, Shang-Ze; Huang, Xi-Cheng; Zhang, Xiao-Dong; Li, Chao; Du, Run-Lei; Chen, Jie] Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China.

[Li, Shang-Ze; Song, Xue-Min] Wuhan Univ, Res Ctr Anesthesiol & Crit Care Med, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.

[Liu, Wenbin] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Xue-Min Song] R

[Run-Lei Du] H

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei Province, 430072, PR China<&wdkj&>Research Centre of Anesthesiology and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430071, PR China

语种：

英文

关键词：

CDK4;Colorectal cancer;MYC;Proliferation;PTPN18

期刊：

基因与疾病

ISSN：

2352-4820

年：

2021

卷：

期：

页码：

838-848

DOI：

10.1016/j.gendis.2020.08.001

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (NSFC) ( 81872271 and 81902844 ), Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University ( ZNJC201921 ) and Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund ( znpy2018102 ).

机构署名：

本校为其他机构

院系归属：

医学与健康学院

摘要：

Protein tyrosine phosphatase non-receptor type 18 (PTPN18) is often highly expressed in colorectal cancer (CRC), but its role in this disease remains unclear. We demonstrated that PTPN18 overexpression promotes growth and tumorigenesis in CRC cells and that PTPN18 deficiency yields the opposite results in vitro. Moreover, a xenograft assay showed that PTPN18 deficiency significantly inhibited tumorigenesis in vivo. PTPN18 activated the MYC signaling pathway and enhanced CDK4 expression, which is tightly associated with the cell cycle and prolif...

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PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis

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