期刊论文

Zheng, B

英文

Analytica Chimica Acta

0003-2670

2025

1356

344045

10.1016/j.aca.2025.344045

CRediT authorship contribution statement Han Wu: Writing – original draft, Methodology, Investigation, Conceptualization. Huaiheng Zhou: Methodology, Investigation. Zhanqiang Sun: Supervision. Jiayao Fang: Methodology, Investigation. Weiran An: Methodology, Investigation. Xiaoli Yu: Supervision. Bo Zheng: Writing – review & editing, Supervision, Methodology, Investigation, acquisition, Conceptualization.

本校为其他机构

Background Proteins which are important biomarkers for disease diagnosis, prognosis and treatment are often present at very low concentrations in biological samples. Measuring these low-level proteins is important yet challenging. Conventional enzyme-linked immunoassays (ELISAs) usually lack the sensitive required. While ultrasensitive detection methods, such as digital ELISA have recently significantly advanced in sensitivity, they usually face high-cost of using paramagnetic beads or require complicated substrate fabrication, limiting their a...