Leucine in Obesity: Therapeutic Prospects

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成果类型：

期刊论文

作者：

Yao, Kang;Duan, Yehui;Li, Fengna*;Tan, Bie;Hou, Yongqing;...

通讯作者：

Li, Fengna;Yin, Yulong

作者机构：

[Li, Fengna; Yin, YL; Yao, Kang; Tan, Bie; Duan, Yehui; Wu, Guoyao; Yin, Yulong] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.

[Li, Fengna; Yin, YL; Yao, Kang; Tan, Bie; Duan, Yehui; Wu, Guoyao; Yin, Yulong] Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Changsha 410125, Hunan, Peoples R China.

[Li, Fengna; Yin, YL; Yao, Kang; Tan, Bie; Duan, Yehui; Wu, Guoyao; Yin, Yulong] Minist Agr, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Changsha 410125, Hunan, Peoples R China.

[Yao, Kang; Yin, Yulong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Yin, Yulong] Hunan Normal Univ, Coll Life Sci, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Li, FN; Yin, YL; Li, Fengna] C

[Li, FN; Yin, YL; Yin, Yulong; Li, Fengna] H

[Li, FN; Yin, YL] M

[Yin, Yulong] S

Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.

语种：

英文

期刊：

Trends in Pharmacological Sciences

ISSN：

0165-6147

年：

2016

卷：

期：

页码：

714-727

DOI：

10.1016/j.tips.2016.05.004

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31110103909, 31330075, 31472107, 31572416, 31372319]; National Basic Research Program of ChinaNational Basic Research Program of China [2013CB127305, 2012CB124704]; Youth Innovation Promotion Association CAS; Nature Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2015JJ2146]; Special Fund for Agro-scientific Research in the Public Interest [201403047]; Innovation Research Team Development Program of MOE of China [IRT0945]; Chinese Academy of Science STS Project [KFJ-EW-STS-063]; Key Projects in the National Science & Technology Pillar Program [2013BAD21B04]; Hunan Key Project [2015NK1002]; Changsha Lvye Biotechnology Limited Company Academician Expert Workstation; Guangdong Wangda Group Academician Workstation for Clean Feed Technology Research and Development in Swine; Guangdong Hinapharm Group Academician Workstation for Biological Feed and Feed Additives and Animal Intestinal Health; Hunan New Wellful Co. Ltd. Academician Workstation; Hubei Provincial Key Project for Scientific and Technical Innovation [2014ABA022]; Chinese Academy of Sciences 'Hundred Talent' award; Hubei Hundred Talent program; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2013CFA097, 2013CFB325, 2012FFB04805, 2011CDA131]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

Obesity develops from an imbalance of energy homeostasis and is associated with chronic low-grade inflammation in white adipose tissues (WAT). Inflammation is involved in the pathophysiology of many obesity-induced disorders including insulin resistance and diabetes. Increasing evidence has shown that dietary leucine supplementation positively affects the parameters associated with obesity and obesity-related metabolic disorders. The beneficial effects include increased loss of body weight, reduced WAT inflammation, improved lipid and glucose metabolism, enhanced mitochondrial function, and pr...

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