Indoor nanoscale particulate matter-induced coagulation abnormality based on a human 3D microvascular model on a microfluidic chip

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成果类型：

期刊论文

作者：

Li, Yan;Hu, Chuanlin;Wang, Pengcheng;Liu, Yan;Wang, Luyang;...

通讯作者：

Wu, Yang;Mak, Michael

作者机构：

[Liu, Yan; Gong, Zhiyong; Li, Yan; Wang, Pengcheng] Wuhan Polytech Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Peoples R China.

[Wu, Yang] Wuhan Polytech Univ, Coll Food Sci & Engn, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.

[Li, Yan; Mak, Michael] Yale Univ, Sch Engn & Appl Sci, Dept Biomed Engn, New Haven, CT 06520 USA.

[Wang, Luyang] Tsinghua Univ, Dept Bldg Sci, Beijing 100084, Peoples R China.

[Pi, Qingmeng] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.

通讯机构：

[Wu, Yang] W

[Mak, Michael] Y

Wuhan Polytech Univ, Coll Food Sci & Engn, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.

Yale Univ, Sch Engn & Appl Sci, Dept Biomed Engn, New Haven, CT 06520 USA.

语种：

英文

关键词：

Indoor particulate matter;Oxidative stress;Inflammation;Promote coagulation;3D human microvessel

期刊：

Journal of Nanobiotechnology

ISSN：

1477-3155

年：

2019

卷：

期：

页码：

1-17

DOI：

10.1186/s12951-019-0458-2

基金类别：

This work was financially supported by the Natural Science Foundation of China (Grant No. 21607117). Profound appreciation and the sincerest thanks are offered to National Natural Science Foundation of China funding the current work (Grant No. 21607117).

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Background: A growing body of evidence shows that indoor concentrations of airborne particles are often higher than is typically encountered outdoors. Since exposure to indoor PM2.5 is thought to be associated with cardiovascular disease, the health impacts of indoor air pollution need to be explored. Based on animal models, ambient particulate matter has been proved to promote coagulation which is very likely involved in the pathogenic development of cardiovascular disease. However, animal models are insufficient to predict what will happen wi...

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Indoor nanoscale particulate matter-induced coagulation abnormality based on a human 3D microvascular model on a microfluidic chip

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