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Ultrahigh pressure field: A friendly pathway for regulating the cellular adhesion and migration capacity of collagen

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成果类型:
期刊论文
作者:
Xu, Chengzhi;Xiao, Xiao;Hu, Wenjing;Zhu, Lian;Kou, Huizhi;...
通讯作者:
Wang, HB
作者机构:
[Xu, Chengzhi; Hu, Wenjing; Wei, Benmei; Zhu, Lian; Kou, Huizhi; Zhang, Juntao] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan, Hubei, Peoples R China.
[Xiao, Xiao] Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan, Hubei, Peoples R China.
[Wang, Haibo] Hubei Engn Univ, Coll Life Sci & Technol, Hubei Key Lab Qual Control Characterist Fruits & V, Xiaogan, Hubei, Peoples R China.
通讯机构:
[Wang, HB ] H
Hubei Engn Univ, Coll Life Sci & Technol, Hubei Key Lab Qual Control Characterist Fruits & V, Xiaogan, Hubei, Peoples R China.
语种:
英文
关键词:
Cellular responsiveness;Collagen;Ultrahigh pressure
期刊:
International Journal of Biological Macromolecules
ISSN:
0141-8130
年:
2024
卷:
257
期:
Pt 1
页码:
127864
基金类别:
National Natural Science Foundation of China [22178277]
机构署名:
本校为第一机构
院系归属:
食品科学与工程学院
化学与环境工程学院
摘要:
Customized control of the biological response between the material matrix and cells is a crucial aspect in the development of the next generation of collagen materials. This study aims to investigate the effects of ultrahigh pressure treatment on the interaction between collagen and cells by subjecting bovine tendon collagen to different intensities of ultrahigh pressure field. The results indicate that ultrahigh pressure treatment alters the spatial folding of collagen, causing distortion of its triple helical conformation and exposing more free amino groups and hydrophobic regions. As a resu...

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