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Medium-Chain Triglycerides Attenuate Liver Injury in Lipopolysaccharide-Challenged Pigs by Inhibiting Necroptotic and Inflammatory Signaling Pathways

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成果类型:
期刊论文
作者:
Zhang, Lin;Wang, Xiuying;Chen, Shaokui;Wang, Shuhui;Tu, Zhixiao;...
通讯作者:
Liu, Yulan
作者机构:
[Zhang, Guolong; Liu, Yulan; Chen, Shaokui; Xiong, Jianglin; Wang, Shuhui; Tu, Zhixiao; Li, Xiangen; Zhang, Lin; Wang, Xiuying; Zhu, Huiling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.
[Zhang, Guolong] Oklahoma State Univ, Dept Anim Sci, Stillwater, OK 74078 USA.
通讯机构:
[Liu, Yulan] W
Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
关键词:
alanine aminotransferase;alkaline phosphatase;aspartate aminotransferase;caspase recruitment domain protein 4;claudin 1;docosahexaenoic acid;heat shock protein 70;icosapentaenoic acid;interleukin 1beta;interleukin 6;lipopolysaccharide;medium chain triacylglycerol;messenger RNA;mitogen activated protein kinase 1;mitogen activated protein kinase 3;mitogen activated protein kinase p38;mixed lineage kinase domain like protein;phosphoglycerate mutase;polyunsaturated fatty acid;protein serine threonine kinase;toll like receptor 4;tumor necrosis factor;unclassified drug;alanine aminotransferase;alkaline phosphatase;antiinflammatory agent;caspase recruitment domain protein 4;cytokine;lipopolysaccharide;omega 3 fatty acid;toll like receptor 4;triacylglycerol;animal experiment;animal model;animal tissue;Article;autophagosome;cell infiltration;controlled study;diet supplementation;down regulation;enzyme linked immunosorbent assay;factorial design;histology;lipid composition;liver injury;membrane rupture;mitochondrion swelling;necroptosis;nonhuman;pig;protein expression;protein phosphorylation;real time polymerase chain reaction;renal protection;signal transduction;transmission electron microscopy;Western blotting;animal;apoptosis;blood;dietary supplement;drug effect;genetics;liver cell;liver disease;MAPK signaling;metabolism;randomization;Alanine Transaminase;Alkaline Phosphatase;Animals;Anti-Inflammatory Agents;Apoptosis;Cytokines;Dietary Supplements;Fatty Acids, Omega-3;Hepatocytes;Lipopolysaccharides;Liver Diseases;MAP Kinase Signaling System;Nod1 Signaling Adaptor Protein;Random Allocation;Swine;Toll-Like Receptor 4;Triglycerides
期刊:
International Journal of Molecular Sciences
ISSN:
1661-6596
年:
2018
卷:
19
期:
11
页码:
3697-
基金类别:
This study was financially supported by the National Natural Science Foundation of China (31772615), the State’s Key Project of Research and Development Plan (2016YFD0501210) and the Project of the Hubei Provincial Department of Education (T201508).
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
This study was conducted to investigate whether medium-chain triglycerides (MCTs) attenuated lipopolysaccharide (LPS)-induced liver injury by down-regulating necroptotic and inflammatory signaling pathways. A total of 24 pigs were randomly allotted to four treatments in a 2 × 2 factorial design including diet (0 and 4% MCTs) and immunological challenge (saline and LPS). After three weeks of feeding with or without 4% MCTs, pigs were challenged with saline or LPS. MCTs led to a significant increase in eicosapentaenoic acid, docosahexaenoic acid...

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