期刊论文

Hou, Yongqing

英文

Amino Acids

0939-4451

2016

48

2

523-533

10.1007/s00726-015-2105-z

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31372319, 31572416, 31402084]; Hubei Provincial Key Project for Scientific and Technical Innovation [2014ABA022]; Hubei Provincial Research and Development Program [2010BB023]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2013CFA097, 2012FFB04805, 2011CDA131]; Hubei Hundred Talent Program; Agriculture and Food Research Initiative Competitive Grants of USDA National Institute of Food and Agriculture [2014-67015-21770]; Texas A&M AgriLife Research [H-82000]

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Dietary supplementation with N-acetylcysteine (NAC) has been reported to improve intestinal health and treat gastrointestinal diseases. However, the underlying mechanisms are not fully understood. According to previous reports, NAC was thought to exert its effect through glutathione synthesis. This study tested the hypothesis that NAC enhances enterocyte growth and protein synthesis independently of cellular glutathione synthesis. Intestinal porcine epithelial cells were cultured for 3 days in Dulbecco's modified Eagle medium containing 0 or 10...