Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis:

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成果类型：

期刊论文

作者：

Guo, Ling;Li, Linna;Zhang, Yang;Fu, Shulin;Zhang, Jing;...

通讯作者：

Liu, Yulan

作者机构：

[Zhang, Yang; Zhang, Jing; Wu, Lingying; Liu, Yulan; Li, Linna; Fu, Shulin; Wang, Xiuying; Guo, Ling; Zhu, Huiling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

[Zhang, Yang; Zhang, Jing; Wu, Lingying; Liu, Yulan; Fu, Shulin; Wang, Xiuying; Guo, Ling; Zhu, Huiling] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan, Hubei, Peoples R China.

[Qiao, Mu] Hubei Acad Agr Sci, Key Lab Anim Embryo Engn & Mol Breeding Hubei Pro, Inst Anim Husb & Vet, Wuhan, Hubei, Peoples R China.

通讯机构：

[Liu, Yulan] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

Long non-coding RNA;lipopolysaccharide;intestinal inflammation;cam signalling pathway;mTOR signalling pathway

期刊：

INNATE IMMUNITY

ISSN：

1753-4259

年：

2019

卷：

期：

页码：

491-502

DOI：

10.1177/1753425919872812

基金类别：

Project of the Hubei Provincial Department of Education [T201508]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31601922]; Project of Wuhan Science and Technology Bureau [2018020401011304]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

LPS can induce an inflammatory immune response in the intestine, and long non-coding RNA (lncRNA) is involved in the process of inflammatory disease. However, the biological role of lncRNA in the intestinal inflammation of piglets remains unclear. In this study, the lncRNA expression profile of the ileal mucosa of piglets challenged by LPS was analysed using lncRNA sequencing. In total, 112 novel lncRNAs were predicted, of which 58 were up-regulated and 54 down-regulated following LPS challenge. Expression of 15 selected lncRNAs was validated by quantitative PCR. We further investigated the ta...

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Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis:

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