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Glycine Alleviated Intestinal Injury by Inhibiting Ferroptosis in Piglets Challenged with Diquat

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成果类型:
期刊论文
作者:
Xu, Xiao;Wei, Yu;Hua, Hongwei;Zhu, Huiling;Xiao, Kan;...
通讯作者:
Yulan Liu
作者机构:
[Hua, Hongwei; Xu, Xiao; Liu, Yulan; Xiao, Kan; Wei, Yu; Zhu, Huiling] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
[Zhao, Jiangchao] Univ Arkansas, Dept Anim Sci, Div Agr, Fayetteville, AR 72701 USA.
通讯机构:
[Yulan Liu] H
Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>Author to whom correspondence should be addressed.
语种:
英文
关键词:
ferroptosis;glycine;intestinal mucosa;oxidative stress;weanling piglets
期刊:
ANIMALS
ISSN:
2076-2615
年:
2022
卷:
12
期:
22
页码:
3071-
基金类别:
Conceptualization, X.X., J.Z. and Y.L.; methodology, X.X., H.H., H.Z., J.Z. and K.X.; software, H.H., J.Z. and Y.W.; validation, X.X. and Y.L.; formal analysis, H.Z. and K.X.; investigation, Y.W. and H.H; resources, X.X. and K.X.; data curation, H.H. and Y.W.; writing—original draft preparation, Y.W. and X.X.; writing—review and editing, K.X., J.Z. and Y.W.; visualization, H.Z. and J.Z.; supervision, Y.L.; project administration, X.X., J.Z. and Y.L.; funding acquisition, Y.L. All authors have read and agreed to the published version of the manuscript. This research and APC were funded by the National Natural Science Foundation of China (No. 32272918), the Dawn Project in Special Project of Knowledge Innovation of Wuhan (No. 2022020801020396), the Scientific Research Project of Wuhan Polytechnic University (NO. 2022J05).
机构署名:
本校为第一机构
院系归属:
动物科学与营养工程学院
摘要:
Simple Summary Oxidative stress may reduce the growth performance and intestinal health status of weanling piglets. Due to the fact that the body can synthesize glycine, it is generally treated as an amino acid which is nonessential for nourishment. However, previous research has demonstrated that synthesized glycine was unable to support piglets' newborn growth and development. Moreover, according to several findings, glycine is crucial for relieving oxidative stress and intestinal damage. The purpose of this investigation was to determine whether glycine could lessen the intestinal damage ca...

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