Evaluation of recombinant protein superoxide dismutase of Haemophilus parasuis strain SH0165 as vaccine candidate in a mouse model

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成果类型：

期刊论文

作者：

Guo, Ling;Xu, Lei;Wu, Tao;Fu, Shulin*;Qiu, Yinsheng*;...

通讯作者：

Fu, Shulin;Qiu, Yinsheng

作者机构：

[Wu, Tao; Hu, Chien-An Andy; Xu, Lei; Qiu, Yinsheng; Fu, Shulin; Guo, Ling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Hu, Chien-An Andy] Univ New Mexico, Sch Med, Biochem & Mol Biol, Albuquerque, NM 87131 USA.

[Ren, Xinglong] Huazhong Agr Univ, Coll Sci, Wuhan 430070, Peoples R China.

[Ye, Mengdie; Liu, Rongrong] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Fu, SL; Qiu, YS] W

Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Haemophilus parasuis;Glässer’s disease;superoxide dismutase;vaccine;Haemophilus parasuis;maladie de Glässer;superoxyde dismutase;vaccin

期刊：

CANADIAN JOURNAL OF MICROBIOLOGY

ISSN：

0008-4166

年：

2017

卷：

期：

页码：

312-320

DOI：

10.1139/cjm-2016-0671

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31402225, 31572572, 31302089, 31601922]; Natural Science Foundation of Hubei Province, ChinaNatural Science Foundation of Hubei Province [2014CFB345, 2014CFC1022, 2012FFBO4804]; Youth Science and Technology of Wuhan Morning program [2015070404010194]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Haemophilus parasuis can cause a severe membrane inflammation disorder. It has been documented that superoxide dismutase (SOD) is a potential target to treat systemic inflammatory diseases. Therefore, we constructed an experimental H. parasuis subunit vaccine SOD and determined the protective efficacy of SOD using a lethal dose challenge against H. parasuis serovar 4 strain MD0322 and serovar 5 strain SH0165 in a mouse model. The results demonstrated that SOD could induce a strong humoral immune response in mice and provide significant immunopr...

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Evaluation of recombinant protein superoxide dismutase of Haemophilus parasuis strain SH0165 as vaccine candidate in a mouse model

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