期刊论文

Effects of baicalin on inflammatory cytokines expression in serum and tissues of piglets stimulated by lipopolysaccharide

中文

黑龙江畜牧兽医

1004-7034

2020

03

110-115,119

10.13881/j.cnki.hljxmsy.2019.04.0259

国家自然科学基金项目(31572572)。

本校为第一机构

为评价黄芩苷的抗炎作用,研究黄芩苷对脂多糖(LPS)刺激后仔猪血清中炎性因子表达的影响,试验选取36头健康状况良好、体重(11.0±1.2) kg的"杜×长×大"断奶仔猪,随机分为阴性对照组、LPS组、氟尼辛葡甲胺组和黄芩苷组(黄芩苷剂量分别为按体重25,50,100 mg/kg添加)6组。饲喂7 d后,氟尼辛葡甲胺组和黄芩苷组提前0.5 h肌肉注射给药,然后与LPS组一起按体重0.1 mg/kg腹腔注射LPS,阴性对照组腹腔注射等量生理盐水,注射LPS 6 h后再次给药1次。检测注射LPS后3,24小时时猪血清中炎性因子TNF-α、IL-1β、IL-6和IL-8的含量,并于注射LPS 24 h后检测血管和腹膜中炎性因子TNF-α、IL-1β、IL-6和IL-8的基因表...

To evaluate the anti-inflammatory effects of baicalin,the effects of baicalin on the expression of inflammatory cytokines in serum of piglets stimulated by lipopolysaccharide(LPS)was studied.Thirty-six"Du×Chang×Da"weaned piglets with good health and similar body weight were randomly divided into 6 groups:negative control group,LPS model group,flunixin Methylamine treatment group and baicalin treatment group(the dose of baicalin was 25,50,100 mg/kg body weight,respectively).On the 7th day,the LPS model group and the drug-treated group were int...