Farnesoid X receptor (FXR) is an important regulator of glucose and lipid homeostasis. However, the exact role of FXR in diabetes remains to be fully elucidated. The present study examined the effects of chenodeoxycholic acid (CDCA), an agonist of FXR, on metabolism profile in a rat model of type 2 diabetes mellitus (T2DM). Male Wistar rats (8-week-old; n=40) were randomized into the following four groups (n=10): Untreated control, CDCA-treated, T2DM, and CDCA-treated T2DM. To establish the T2DM model, the rats were fed a high-fat diet (HFD) fo...