期刊论文

Experimental study on SOD, GSH - Px、 CAT, MDA effects in mice blood of KOTAIS

中文

中国民族民间医药

1007-8517

2009

18

24

40-41

10.3969/j.issn.1007-8517.2009.24.026

基金项目：武汉工业学院科研资助课题（编号：05Y61）

本校为第一机构

目的:通过测定小鼠血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、过氧化氢酶(CAT)的活性和丙二醛(MDA)含量来研究康泰仙(KOTAIS)对小鼠抗衰老的作用.方法:采用D-半乳糖制作的衰老模型,将小鼠随机分为正常组、模型组、药物低、中、高剂量组.连续给药灌胃60d后,检测哀老相关指标.结果:各剂量组能提高小鼠血液中SOD、GSH-Px、CAT的活性,并能降低MDA的含量.以中剂量组尤其明显.结论:康泰仙(KOTAIS)具有较好的消除自由基、抗衰老的作用.

OBJECTIVE： To study the anti - aging effects of KOTAIS on model mice by measuring SOD, GSH - Px, CAT, MDA levels of blood. METHODS ： Random groups were prepared by weight for 5 groups and were given normal, D - galactose, and the low and middle and high of KOTAIS. Interrelated senile indexes were measured after successively give medicine for 60 days . RESULTS ： Every dose group is able to improve the activities of SOD and GSH - Px and CAT and decrease the level of MDA in blood of all mice. The effects of anti - aging is very obviously for middle dose group. CONCLUSIO...