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18β-glycyrrhetinic acid alleviates p. Multocida- induced vascular endothelial inflammation by parpi-mediated nf-κb and hmgbi signalling suppression in piec cells

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成果类型:
期刊论文
作者:
Lu, Qirong;Han, Wantong;Wen, Defeng;Guo, Pu;Liu, Yu;...
通讯作者:
Pu Guo
作者机构:
[Wen, Defeng; Han, Wantong; Liu, Yu; Guo, Pu; Ye, Chun; Qiu, Yinsheng; Wu, Zhongyuan; Fu, Shulin; Lu, Qirong] Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, 430023, People's Republic of China
[Wang, Xu] National Reference Laboratory of Veterinary Drug Residues (HZAU) and Ministry of Agriculture Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, People's Republic of China
通讯机构:
[Pu Guo] H
Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, 430023, People’s Republic of China
语种:
英文
关键词:
GA;P. multocida infection;PARP1;inflammatory injury;network pharmacology
期刊:
INFECTION AND DRUG RESISTANCE
ISSN:
1178-6973
年:
2023
卷:
16
期:
Volume 16, 2023 - Issue
页码:
4201-4212
基金类别:
This work was supported by National Natural Science Foundation of China (NSFC) (32202867) and Key Research and Development Plan of Hubei Province, China (2022BBA0055).
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
BACKGROUND: At present, the treatment and prevention of Pasteurella multocida infections in pigs mainly rely on antibiotics and vaccines, but inflammatory injury cannot be eliminated. The compound 18β-glycyrrhetinic acid (GA), a pentacyclic triterpenoid extracted from Glycyrrhiza glabra L. root (liquorice) and with a chemical structure similar to that of steroidal hormones, has become a research focus because of its anti-inflammatory, antiulcer, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and neuroprotective effects, but its...

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