Complex regulation of capsaicin on intracellular second messengers by calcium dependent and independent mechanisms in primary sensory neurons

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成果类型：

期刊论文

作者：

Xu, Yu-ping;Zhang, Jie-wen;Li, Li;Ye, Zeng-you;Zhang, Yi*;...

通讯作者：

Zhang, Yi

作者机构：

[Xu, Yu-ping; Zhang, Jie-wen] Henan Prov Peoples Hosp, Dept Dermatol, Zhengzhou, Henan, Peoples R China.

[Zhang, Yi] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Anesthesiol, Wuhan 430074, Hubei, Peoples R China.

[Li, Li; Ye, Zeng-you; Cao, Xue-hong] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.

[Yan, Xi-sheng; Gao, Xiang; Cao, Xue-hong; Li, Fen] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China.

[Liu, Lie-ju; Liu, Zhi-guo; Cao, Xue-hong] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Zhang, Yi] H

Huazhong Univ Sci & Technol, Tongji Hosp, Dept Anesthesiol, Wuhan 430074, Hubei, Peoples R China.

语种：

英文

关键词：

Capsaicin;Intracellular second messenger;Nociceptors;Pain;TRPV1 receptor

期刊：

Neuroscience Letters

ISSN：

0304-3940

年：

2012

卷：

517

期：

页码：

30-35

DOI：

10.1016/j.neulet.2012.04.011

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30271500, 30571537]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Intracellular second messengers play an important role in capsaicin- and analogous-induced sensitization and desensitization in pain. Fluorescence Ca2+ imaging, enzyme immunoassay and PKC assay kit were used to determine a novel mechanism of different Ca2+ dependency in the signal transduction of capsaicin-induced desensitization. On the average, capsaicin increased cAMP, cGMP concentration and SP release in bell-shaped concentration-dependent manner, with the maximal responses at concentrations around 1 mu M, suggesting acute desensitization of TRPV1 receptor activation. Capsaicin-induced int...

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Complex regulation of capsaicin on intracellular second messengers by calcium dependent and independent mechanisms in primary sensory neurons

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