The Agr-Like Quorum Sensing System Is Required for Pathogenesis of Necrotic Enteritis Caused by Clostridium perfringens in Poultry

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成果类型：

期刊论文

作者：

Yu, Qiang;Lepp, Dion;Gohari, Iman Mehdizadeh;Wu, Tao;Zhou, Hongzhuan;...

通讯作者：

Xie, Ming-Yong;Gong, Joshua

作者机构：

[Yu, Qiang; Nie, Shao-Ping; Xie, Ming-Yong] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang, Jiangxi, Peoples R China.

[Wu, Tao; Lepp, Dion; Gong, Joshua; Yin, Xianhua; Zhou, Hongzhuan; Yu, Qiang; Yu, Hai] Agr & Agri Food Canada, Guelph Res & Dev Ctr, Guelph, ON, Canada.

[Gohari, Iman Mehdizadeh; Prescott, John F.] Univ Guelph, Dept Pathobiol, Guelph, ON, Canada.

[Wu, Tao] Wuhan Polytechn Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Hubei, Peoples R China.

[Zhou, Hongzhuan] Beijing Acad Agr & Forestry Sci, Beijing Agrobiotechnol Res Ctr, Beijing, Peoples R China.

通讯机构：

[Xie, Ming-Yong] N

[Gong, Joshua] A

Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang, Jiangxi, Peoples R China.

Agr & Agri Food Canada, Guelph Res & Dev Ctr, Guelph, ON, Canada.

语种：

英文

关键词：

*Agr-like quorum sensing;*Clostridium perfringens;*LuxS;*NetB;*VirS/VirR;*necrotic enteritis;*poultry;*quorum sensing

期刊：

Infection and Immunity

ISSN：

0019-9567

年：

2017

卷：

期：

DOI：

10.1128/IAI.00975-16

基金类别：

Agriculture and Agri-Food CanadaAgriculture & Agri Food Canada; Canadian Poultry Research Council; China Scholarship Council through the MOE-AAFC Ph.D. Research ProgramChina Scholarship Council; China Scholarship CouncilChina Scholarship Council

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

ABSTRACT Clostridium perfringens encodes at least two different quorum sensing (QS) systems, the Agr-like and LuxS, and recent studies have highlighted their importance in the regulation of toxin production and virulence. The role of QS in the pathogenesis of necrotic enteritis (NE) in poultry and the regulation of NetB, the key toxin involved, has not yet been investigated. We have generated isogenic agrB -null and complemented strains from parent strain CP1 and demonstrated that the virulence of the agrB -null mutant was strongly attenuated in a chicken NE model system and restored b...

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The Agr-Like Quorum Sensing System Is Required for Pathogenesis of Necrotic Enteritis Caused by Clostridium perfringens in Poultry

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