CRediT authorship contribution statement Qingkun Ma: Writing – original draft, Visualization, Investigation, Data curation, Conceptualization. Xizhu Xu: Writing – original draft, Formal analysis. Kang An: Writing – original draft, Formal analysis. Jie Cai: Formal analysis. Ling Meng: Writing – review & editing, Writing – original draft, Visualization, Supervision, Methodology, Investigation, acquisition, Data curation, Conceptualization. This work was supported by Natural Science Foundation of Shandong Province (ZR2023MC151); Young People Fund of Shandong First Medical University (202201–030).