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Molecular cloning and functional characterization of cyclophilin A in yellow catfish (Pelteobagrus fulvidraco)

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成果类型:
期刊论文
作者:
Dong, Xingxing;Qin, Zhendong;Hu, Xianqin;Lan, Jiangfeng;Yuan, Gailing;...
通讯作者:
Mei, Jie
作者机构:
[Hu, Xianqin; Dong, Xingxing; Asim, Muhammad; Zhou, Yang; Qin, Zhendong; Lan, Jiangfeng; Lin, Li; Yuan, Gailing] Huazhong Agr Univ, Coll Fisheries, Dept Aquat Anim Med, Wuhan 430070, Hubei, Peoples R China.
[Dong, Xingxing; Zhou, Yang; Qin, Zhendong; Lan, Jiangfeng; Mei, Jie; Lin, Li; Yuan, Gailing] Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan 430070, Hubei, Peoples R China.
[Hu, Xianqin] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Hubei, Peoples R China.
[Ai, Taoshan] Wuhan Fishery Res Inst, Wuhan 430207, Hubei, Peoples R China.
[Mei, Jie; Lin, Li] Minist Agr, Key Lab Freshwater Anim Breeding, Wuhan 430070, Hubei, Peoples R China.
通讯机构:
[Mei, Jie] H
Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China.
语种:
英文
关键词:
Pelteobagrus fulvidraco;Cyclophilin A;Chemotactic activity;Expression;Edwardsiella ictaluri
期刊:
Fish & Shellfish Immunology
ISSN:
1050-4648
年:
2015
卷:
45
期:
2
页码:
422-430
基金类别:
This work was jointly supported by the Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ( 52204-12020 ), Fundamental Research Funds for the Central Universities ( 2013PY069 , 2014PY035 ), grant from Wuhan Chopper Fishery Co. Ltd ( 720107-137076 ), and Natural Science Foundation of China ( 31372563 ) awarded to L Lin; Natural Science Foundation of China ( 31402341 ) and the Postdoctoral Science Foundation ( 2014M550400 ) awarded to Y Zhou.
机构署名:
本校为其他机构
院系归属:
动物科学与营养工程学院
摘要:
Cyclophilin A (CypA) is a ubiquitously expressed protein which involves in diverse pathological conditions including infection and inflammation. In this report, a CypA gene (designated as YC-CypA) was cloned from yellow catfish (Pelteobagrus fulvidraco) which is an important cultured fish species in Asian countries. The open reading frame (ORF) of YC-CypA encoded a polypeptide of 164 amino acids with calculated molecular weight of 17.70 kDa. The deduced amino acid sequences of the YC-CypA shared highly conserved structures with CypAs from the other species, indicating that YC-CypA should be a ...

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