期刊论文

Li, Lan

英文

Molecular & Cellular Toxicology

1738-642X

2018

14

2

143-153

10.1007/s13273-018-0016-2

Acknowledgements This work was supported by Science and Technology Development Plan Project of Medicine and Health Department of Shandong Province (2016 WS0627) and the Fund for Doctoral Scientific research Startup of Qingdao agricultural University (6631116019).

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Backgrounds: Di-(2-ethylhexyl) phthalate (DEHP), as an endocrine-disrupting chemical (EDC), is widely used in plasticizer and other productions. Ubiquitous human exposure to DEHP has been proposed to be a potential risk to public health. Developmental exposure to DEHP could alter epigenetic programming and result in adult-onset disease. Methods: In this study, we investigated whether DEHP exposure to pregnant mice affected epigenetic changes as a result of increase in breast cancer incidence. Results: Our results showed that the expression of t...