OBJECTIVE To analyze the coverage rate of DTaP-IPV/Hib vaccine and to evaluate its replacement for the Poliovi-rus Vaccine(PV)among children aged 0~6 in Wuhan from 2016 to 2022.METHODS The birth cohort of 0~6 years old in Wuhan from 2016 to 2022 was established through the children vaccination data of Hubei Immunization Program Information Management System,and the epidemiological analysis of penta vaccination coverage rate and replacement rate was carried out.RESULTS By the end of 2022,the cumulative coverage rate of one to four doses of pen...