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NMR-based plasma metabonomics in hyperlipidemia mice

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成果类型:
期刊论文
作者:
Li, Yun;Zhao, Xiu-ju*
通讯作者:
Zhao, Xiu-ju
作者机构:
[Li, Yun; Zhao, Xiu-ju] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, 68 South Xuefu Rd, Wuhan 430023, Peoples R China.
[Zhao, Xiu-ju] Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Peoples R China.
通讯机构:
[Zhao, Xiu-ju] W
Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, 68 South Xuefu Rd, Wuhan 430023, Peoples R China.
Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Peoples R China.
语种:
英文
期刊:
ANALYTICAL METHODS
ISSN:
1759-9660
年:
2020
卷:
12
期:
15
页码:
1995-2001
基金类别:
Z. X. J. wrote the main manuscript text and L. Y. prepared Fig. 1– 4. All authors reviewed the manuscript. This work was supported by the Key Science and Technology Program of Hubei Department of Education (D20191603).
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
生命科学与技术学院
摘要:
Hyperlipidemia dynamics need to be elucidated. 90 Kunming male mice were randomly divided into 18 groups, control groups, and high fat diet groups at 9 time points. On days 7, 10, 15, 18, 21, 24, 28, 31, and 35, the mice were anesthetized and blood was collected into tubes from the eyes. Sections of livers were taken. The plasma glycerol, glucose, leucine, arginine, betaine, lysine, glutamine, glutamate, valine, alanine, and choline were significantly different between the high fat diet groups and the corresponding controls (P < 0.05; VIP > 1)....

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