Plasma and tissue kinetics of enrofloxacin and its metabolite, ciprofloxacin, in yellow catfish (Pelteobagrus fulvidraco) after a single oral administration at different temperatures

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成果类型：

期刊论文

作者：

Xu, Ning*;Sun, Weiyu;Zhang, Huan;Liu, Yongtao;Dong, Jing;...

通讯作者：

Xu, Ning;Ai, XH

作者机构：

[Liu, Yongtao; Zhang, Huan; Ai, Xiaohui; Yang, Qiuhong; Xu, Ning; Sun, Weiyu; Yang, Yibin; Dong, Jing; Zhou, Shun] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China.

[Liu, Yongtao; Ai, Xiaohui; Yang, Qiuhong; Xu, Ning; Yang, Yibin; Dong, Jing; Zhou, Shun] Hu Bei Prov Engn & Technol Res Ctr Aquat Prod Qual, Wuhan 430223, Peoples R China.

[Zhang, Huan; Sun, Weiyu] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.

[Xu, Ning; Ai, Xiaohui; Ai, XH] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Pk Rd 1, Wuhan 430223, Hubei, Peoples R China.

通讯机构：

[Xu, N; Ai, XH ] C

Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Pk Rd 1, Wuhan 430223, Hubei, Peoples R China.

语种：

英文

关键词：

Ciprofloxacin;Different temperatures;Enrofloxacin;Pharmacokinetics;Yellow catfish

期刊：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

ISSN：

1532-0456

年：

2023

卷：

266

页码：

109554

DOI：

10.1016/j.cbpc.2023.109554

基金类别：

The authors would like to appreciate the financial support from the National Natural Science Foundation of China ( 32173022 ), the Agriculture Research System of China ( CARS-46 ), the National Key Research and Development Program of China ( 2019YFD0901701 ), and the Major Technological Innovation of Hubei Province of China ( 2019ABA077 ).

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

The objective of this study was to examine the pharmacokinetic (PK) properties of enrofloxacin (EF) and its metabolite, ciprofloxacin (CF), in yellow catfish (Pelteobagrus fulvidraco) after a single oral dose of EF at 20 mg/ kg at 20, 25, and 30 degrees C. Samples were collected at pre-designed time points and determined by high-performance liquid chromatography with a fluorescent detector. Results showed that most concentrations of EF and CF in plasma and tissues at the same time point at different temperatures were statistically significant. With the increase in temperature, the terminal hal...

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Plasma and tissue kinetics of enrofloxacin and its metabolite, ciprofloxacin, in yellow catfish (Pelteobagrus fulvidraco) after a single oral administration at different temperatures

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