期刊论文

He, X

英文

Cancer Gene Therapy

0929-1903

2025

1-13

10.1038/s41417-025-00942-4

This research was funded by the Natural Science Foundation of Hubei Province, grant number 2022CFB138 to Huili Li; by the Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, grant number 2023zsyx003 to Huili Li; by the Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, grant number 202415 to Huili Li; by the Natural Science Foundation of Hubei Province, grant number 2025AFB304 to Xiangwei Zeng.

本校为第一机构

Ferroptosis, a form of iron-dependent cell death, is emerging as a potential therapeutic target due to its ability to inhibit tumor growth and enhance immune responses. However, the mechanisms regulating ferroptosis and tumor metastasis, particularly in colorectal cancer (CRC), remain poorly understood. In this study, bioinformatics analysis identified MC1R as a key regulator of ferroptosis-related genes. In vitro experiments showed MC1R overexpression in CRC cell lines promotes cell proliferation and migration while inhibiting ferroptosis via downregulating ACSL4 expression, with opposite eff...