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A novel vanadium complex VO(p-dmada) inhibits neuroinflammation induced by lipopolysaccharide

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成果类型:
期刊论文
作者:
He, Zhijun;Li, Xiaoqian;Zhang, Huajie;Liu, Xin;Han, Shuangxue;...
通讯作者:
Li, Nan;Liu, Q;Yang, XD;Li, N
作者机构:
[Du, Xiubo; Zhang, Huajie; Li, Nan; Han, Shuangxue; Shen, Liming; Liu, Qiong; Li, Xiaoqian; Abdurahman, Anwar; He, Zhijun] Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen Key Lab Marine Biotechnol & Ecol, Shenzhen 518055, Peoples R China.
[He, Zhijun] Wuhan Polytech Univ, Natl R&D Ctr Se Rrich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pro, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.
[Du, Xiubo; Liu, Qiong] Shenzhen Bay Lab, Shenzhen 518055, Peoples R China.
[Yang, Xiaoda; Yang, XD] Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, State Key Labs Nat & Biomimet Drugs,Hlth Sci Ctr, Beijing 100191, Peoples R China.
[Liu, Xin] Jinan Univ, Shenzhen Peoples Hosp, Dept Pharm, Clin Med Coll 2, Shenzhen 518020, Peoples R China.
通讯机构:
[Liu, Q ; Li, N; Li, N ] S
[Yang, XD ] P
Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen Key Lab Marine Biotechnol & Ecol, Shenzhen 518055, Peoples R China.
Shenzhen Bay Lab, Shenzhen 518055, Peoples R China.
Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, State Key Labs Nat & Biomimet Drugs,Hlth Sci Ctr, Beijing 100191, Peoples R China.
语种:
英文
关键词:
Microglia;Neuroinflammation;Peroxisome proliferator activated receptor gamma (PPARγ);Proteomics;Vanadium;Vanadyl N-(p-N,N-dimethylaminophenylcarbamoylmethyl)iminodiacetate (VO(p-dmada))
期刊:
中国化学快报:英文版
ISSN:
1001-8417
年:
2023
卷:
34
期:
10
页码:
225-230
基金类别:
This study was financially supported by grants from the National Natural Science Foundation of China (No. 21877081 ), the China Postdoctoral Science Foundation (No. 2021M692210 ), Guangdong Provincial Key S&T Program (No. 2018B030336001 ), the Shenzhen Science and Technology Innovation Commission (No. JCYJ20200109110001818 ), and the Shenzhen-Hong Kong Institute of brain Science-Shenzhen Fundamental Research institutions (No. 2022SHIBS0003 ). We would like to thank the Instrumental Analysis Center of Shenzhen University and the Central Research Facilities of College of Life Sciences and Oceanography of Shenzhen University for the use of laser scanning confocal microscope.
机构署名:
本校为其他机构
院系归属:
硒科学与工程现代产业学院
摘要:
Uncontrolled microglial activation is decisively involved in the neuroinflammatory pathogenesis of brain diseases. Consequently, suppression of microglial overactivation appears to be a strategy for the prevention of nerve injury. In this paper, a novel vanadium complex, vanadyl N -( p-N,N dimethylaminophenylcarbamoylmethyl)iminodiacetate (VO(p-dmada)), was synthesized from vanadyl sulfate and N,N -dimethyl-p-phenylenediamine, which was structurally characterized by Fourier transform infrared spectrum and ESI-MS analysis. The effect of VO(p-dmada) on neuroinflammation was investigated by using...

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