Cadmium influence on lipid metabolism in Sprague-Dawley rats through linoleic acid and glycerophospholipid metabolism pathways

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Mengyuan;Dong, Jingjing;Zhao, Xiaole;Yin, Xiaoyao;Wu, Kejia;...

通讯作者：

Gong, ZY

作者机构：

[Yin, Xiaoyao; Gong, Zhiyong; Wu, Yongning; Wang, Qiao; Chen, Mengyuan; Liu, Xin; Wu, Kejia; Dong, Jingjing; Zhao, Xiaole] Wuhan Polytech Univ, Key Res Inst Humanities & Social Sci Hubei Prov, Coll Food Sci & Engn, Food Safety Res Ctr,Chinese Minist Educ,Key Lab De, Wuhan, Hubei, Peoples R China.

[Wu, Yongning] Chinese Acad Med Sci, China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Food Safety Res Unit 2019RU014, Beijing, Peoples R China.

[Gong, Zhiyong; Gong, ZY] 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Gong, ZY ] 6

68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

cadmium;differential lipid metabolites;pathway analysis;untargeted lipidomics profiling

期刊：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

ISSN：

1095-6670

年：

2023

卷：

期：

页码：

e23412-

DOI：

10.1002/jbt.23412

基金类别：

National Key Research and Development Program of China [2017YFC1600500]

机构署名：

本校为第一机构

院系归属：

食品科学与工程学院

摘要：

Cadmium (Cd) is widely distributed in the environment and easy adsorbed by living organisms with adverse effects. Exposure to Cd-contaminated food may disrupt lipid metabolism and increase human health risk. To study the perturbation effect of Cd on lipid metabolism in vivo, 24 male Sprague-Dawley (SD) rats were randomly assigned four groups and treated by Cd chloride solution (0, 1.375 mg/kg, 5.5 mg/kg, 22 mg/kg) for 14 days. The characteristic indexes of serum lipid metabolism were analyzed. Afterwards, untargeted metabolomics analysis was...

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Cadmium influence on lipid metabolism in Sprague-Dawley rats through linoleic acid and glycerophospholipid metabolism pathways

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