期刊论文

Zhang, Xi-Feng

英文

Molecular Biology Reports

0301-4851

2014

41

3

1227-1235

10.1007/s11033-013-2967-7

National Basic Research Program of China (973 Program)National Basic Research Program of China [2012CB944401]; National Nature Science FoundationNational Natural Science Foundation of China (NSFC) [31201120, 31001010]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-12-1026]; Foundation of Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [JQ201109]; Nature Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2011CDB230]

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Diethylhexyl phthalate (DEHP) is an estrogen-like compound widely used as a plasticizer in commercial products and is present in medical devices, and common household items. It is considered an endocrine disruptor since studies on experimental animals clearly show that exposure to DEHP can alter epigenetics of germ cells. This study was designed to assess the effects of DEHP on DNA methylation of imprinting genes in germ cells from fetal and adult mouse. Pregnant mice were treated with DEHP at doses of 0 and 40 mu g DEHP/kg body weight/day from 0.5 to 18.5 day post coitum. The data revealed DE...