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Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial

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成果类型:
期刊论文
作者:
Wang, Zi-Xian;Cui, Chengxu;Yao, Jun;Zhang, Yanqiao;Li, Mengxia;...
通讯作者:
Xu, Rui-Hua;Wang, F
作者机构:
[Wang, Feng; Xu, Rui-Hua; Wang, Zi-Xian; Xu, RH] Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Dept Med Oncol,Canc Ctr, Guangzhou 510060, Peoples R China.
[Wang, Feng; Xu, Rui-Hua; Wang, Zi-Xian; Xu, RH] Chinese Acad Med Sci, Res Unit Precis Diag & Treatment Gastrointestinal, Guangzhou 510060, Peoples R China.
[Cui, Chengxu] Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China.
[Yao, Jun] Henan Univ Sci & Technol, Affiliated Hosp 1, Luoyang 471000, Peoples R China.
[Zhang, Yanqiao] Harbin Med Univ, Canc Hosp, Harbin 150081, Peoples R China.
通讯机构:
[Wang, F ; Xu, RH] S
Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Dept Med Oncol,Canc Ctr, Guangzhou 510060, Peoples R China.
Chinese Acad Med Sci, Res Unit Precis Diag & Treatment Gastrointestinal, Guangzhou 510060, Peoples R China.
语种:
英文
关键词:
*PD-1 inhibitor;*advanced esophageal squamous cell carcinoma;*double-blind;*immunotherapy;*multi-center;*paclitaxel plus cisplatin;*randomized study
期刊:
Cancer Cell
ISSN:
1535-6108
年:
2022
卷:
40
期:
3
页码:
277-288.e3
基金类别:
This study is sponsored by Shanghai Junshi Biosciences . The authors thank the patients who participated in this study and their families. This work was supported by the Guangdong Esophageal Cancer Institute Science and Technology Program (grant no. M201905 to F.W.), the National Natural Science Foundation of China (grant nos. 81872011 and 82061160373 to F.W.), the Science and Technology Program of Guangdong (grant no. 2019B020227002 to R.-H.X.), the CAMS Innovation Fund for Medical Sciences (grant no. 2019-I2M-5-036 to R.-H.X.), National Major Science & Technology Major Projects (grant no. 2017ZX09302009 to F.H.), and a Shanghai Science and Technology Committee Technology Grant (grant no. 17431900700 to F.H.).
机构署名:
本校为其他机构
摘要:
Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), 514 patients with treatment-naïve advanced ESCC were randomized (1:1) to receive toripalimab or placebo in combination with paclitaxel plus cisplatin (TP) every 3 weeks for up to 6 cycles, followed by toripalimab or placebo maintenance. At the prespecified final analysis of progression-free survival (PFS), a significant improvement in PFS is observed for the toripalimab...

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