期刊论文

Zhang, Weinong

英文

Nanomaterials

2079-4991

2019

9

8

1162-

10.3390/nano9081162

Conceptualization, J.H. and W.Z.; methodology, J.H. and C.C.; formal analysis, S.H., J.H. and X.S.; investigation, S.H. and L.H.; writing—original draft preparation, J.H. and S.H.; assisting experimental design, data analysis and writing—review and editing, Q.Z.; supervision, W.Z.; funding acquisition, X.S. This research was funded by Hubei Provincial Natural Science Foundation of China (No. 2018CFB356), Open Project Program of Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and Business University (SPFW-2018-YB04), “One-Hundred Talents” Program of Hubei Province, and Research and Innovation Initiatives of WHPU (2018Y02). Q.Z. acknowledges hatch projects TEN00487 and 223984 supporting his time spent on this work.

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To develop solid lipid nanoparticles (SLNs) with stable lipid matrix structures for the delivery of bioactive compounds, a new class of SLNs was studied using propylene glycol monopalmitate (PGMP) and glyceryl monostearate (GMS) mixtures and carvacrol as a model lipophilic antimicrobial. Stable SLNs were fabricated at PGMP:GMS mass ratios of 2:1 and 1:1, and the carvacrol loading was up to 30% of lipids with >98% encapsulation efficiency and absence of visual instability. Fluorescence spectra and release profiles indicated the carvacrol was successfully encapsulated and homogeneously distribut...