Carvacrol Loaded Solid Lipid Nanoparticles of Propylene Glycol Monopalmitate and Glyceryl Monostearate: Preparation, Characterization, and Synergistic Antimicrobial Activity

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成果类型：

期刊论文

作者：

He, Junbo;Huang, Shuangshuang;Sun, Xiaotao;Han, Lijuan;Chang, Chao;...

通讯作者：

Zhang, Weinong

作者机构：

[He, Junbo; Zhang, Weinong; Chang, Chao; Han, Lijuan; Huang, Shuangshuang] Wuhan Polytech Univ, Coll Food Sci & Engn, Key Lab Deep Proc Major Grain & Oil, Minist Educ, Wuhan 430023, Hubei, Peoples R China.

[He, Junbo; Zhang, Weinong; Chang, Chao; Han, Lijuan] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.

[Sun, Xiaotao] Beijing Technol & Business Univ, Beijing Key Lab Flavor Chem, Beijing 100048, Peoples R China.

[Zhong, Qixin] Univ Tennessee, Dept Food Sci, Knoxville, TN 37996 USA.

通讯机构：

[Zhang, Weinong] W

Wuhan Polytech Univ, Coll Food Sci & Engn, Key Lab Deep Proc Major Grain & Oil, Minist Educ, Wuhan 430023, Hubei, Peoples R China.

Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

solid lipid nanoparticles;carvacrol;propylene glycol monopalmitate;synergistic antimicrobial activity

期刊：

Nanomaterials

ISSN：

2079-4991

年：

2019

卷：

期：

页码：

1162-

DOI：

10.3390/nano9081162

基金类别：

Funding: This research was funded by Hubei Provincial Natural Science Foundation of China (No. 2018CFB356), Open Project Program of Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and Business University (SPFW-2018-YB04), “One-Hundred Talents” Program of Hubei Province, and Research and Innovation Initiatives of WHPU (2018Y02). Q.Z. acknowledges hatch projects TEN00487 and 223984 supporting his time spent on this work. This research was funded by Hubei Provincial Natural Science Foundation of China (No. 2018CFB356), Open Project Program of Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and Business University (SPFW-2018-YB04), ?One-Hundred Talents? Program of Hubei Province, and Research and Innovation Initiatives of WHPU (2018Y02). Q.Z. acknowledges hatch projects TEN00487 and 223984 supporting his time spent on this work.

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

To develop solid lipid nanoparticles (SLNs) with stable lipid matrix structures for the delivery of bioactive compounds, a new class of SLNs was studied using propylene glycol monopalmitate (PGMP) and glyceryl monostearate (GMS) mixtures and carvacrol as a model lipophilic antimicrobial. Stable SLNs were fabricated at PGMP:GMS mass ratios of 2:1 and 1:1, and the carvacrol loading was up to 30% of lipids with >98% encapsulation efficiency and absence of visual instability. Fluorescence spectra and release profiles indicated the carvacrol was suc...

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Carvacrol Loaded Solid Lipid Nanoparticles of Propylene Glycol Monopalmitate and Glyceryl Monostearate: Preparation, Characterization, and Synergistic Antimicrobial Activity

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