As an efficient method for spectra correction, multivariate scatter correction (MSC) has recently received considerable attention due to the precision improvement of processed data. In general, the spectra approximate mean spectrum S- in least square framework. Unfortunately, the existing MSC methods have a limited capability in nonlinear component modeling. In this paper, we propose regularized multivariate scatter correction (RMSC), which has taken nonlinear components into MSC model as well as regularization function for the weight vector w....