A Novel Immunoprobe Strategy Integrating Tetrahedral DNA Nanostructure and Protein A for Sensitivity Enhancement: Application in Lead Ion Detection

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hao, Xiaotong;Li, Yangyang;Zhu, Zhengwei;Lu, Chenyang;Yang, Qing;...

通讯作者：

Xu, L

作者机构：

[Hao, Xiaotong; Gong, Zhiyong; Li, Yangyang; Xu, Lin; Lu, Chenyang; Liu, Xin; Yang, Qing] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.

[Zhu, Zhengwei] Natl Food & Strateg Reserv Adm, Inst Mat Inspect Hubei Bur, Wuhan 430050, Peoples R China.

[Gong, Zhiyong; Xu, Lin; Liu, Xin; Yang, Qing] Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Peoples R China.

[Xu, Lin; Liu, Xin; Yang, Qing] Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Peoples R China.

[Gong, Zhiyong] Natl Engn Res Ctr Grain Storage & Logist, Beijing 430050, Peoples R China.

通讯机构：

[Xu, L ] W

Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.

Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Peoples R China.

Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

tunable distribution;oriented immobilization;antibody bioactivity;immunochromatographic assay

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2025

卷：

期：

页码：

17901-17908

DOI：

10.1021/acs.jafc.5c02529

基金类别：

National Natural Science Foundation of China [32102072]; Natural Science Foundation of Hubei Province [2025AFB918]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Immunochromatographic assay (ICA) has been extensively utilized for on-site detection to ensure food safety. However, maintaining the bioactivity of immunoprobes while achieving efficient antibody labeling remains a significant challenge. In this study, a novel immunoprobe was developed by integrating tetrahedral DNA nanostructure (TDN) with protein A (PrA) and was subsequently applied in an ICA for the detection of lead ions. Notably, TDN served as a scaffold to enable a tailorable distribution of antibodies, while PrA acted as a bridging ligand to facilitate the oriented immobilization of an...

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A Novel Immunoprobe Strategy Integrating Tetrahedral DNA Nanostructure and Protein A for Sensitivity Enhancement: Application in Lead Ion Detection

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