Antimicrobial peptide CAMA-syn expressed in pulmonary epithelium by recombination adenovirus inhibited the growth of intracellular bacteria

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yue, Shuohao;Jie, Jing;Xie, Lilan;Li, Yi;Zhang, Junlin*;...

通讯作者：

Zhang, Junlin;Lai, Xiaojing

作者机构：

[Yue, Shuohao] Hubei Univ Technol, Coll Bioengn & Food, Minist Educ, Fermentat Engn, Wuhan, Peoples R China.

[Zhang, Junlin] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.

[Lai, Xiaojing] Wuhan Polytech Univ, Coll Hlth ScI Nursing, Wuhan 430023, Hubei, Peoples R China.

[Xie, Lilan; Yue, Shuohao; Jie, Jing; Li, Yi] Wuhan Univ Bioengn, Appl Biotechnol Res Ctr, Hubei Engn Res Ctr Viral Vector, Wuhan, Peoples R China.

[Xie, Jumin] Hubei Polytech Univ, Med Sch, 16 Guilin North Rd, Huangshi, Hubei, Peoples R China.

通讯机构：

[Zhang, Junlin; Lai, Xiaojing] W

Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.

Wuhan Polytech Univ, Coll Hlth ScI Nursing, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

antimicrobial peptide;CAMA-syn;intracellular bacteria;lung epithelial cells

期刊：

JOURNAL OF GENE MEDICINE

ISSN：

1099-498X

年：

2020

卷：

期：

页码：

e3149

DOI：

10.1002/jgm.3149

基金类别：

Hubei Provincial Natural Science Foundation of ChinaNational Natural Science Foundation of China [2017CFB539]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31302148, 31500840]

机构署名：

本校为通讯机构

院系归属：

生命科学与技术学院

摘要：

AbstractBackgroundIntracellular bacteria, especially Mycobacterium tuberculosis, are important pathogenic microorganisms that endanger human health. Purified and synthesized cecropin A‐magainin 2 (CAMA‐syn) can exhibit a higher antibacterial activity and lower cytotoxicity. To enhance such antimicrobial potential, it would be desirable to deliver CAMA‐syn expressed in lung epithelial cells by an adenovirus vector using gene therapy.MethodsA549 cells in vitro and lung epithelial cells in vivo were used to express CAMA‐syn by transducing reco...

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Antimicrobial peptide CAMA-syn expressed in pulmonary epithelium by recombination adenovirus inhibited the growth of intracellular bacteria

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