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N-acetylcysteine and intestinal health: A focus on mechanisms of its actions

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成果类型:
期刊论文
作者:
Hou, Yongqing*;Wang, Lei;Yi, Dan;Wu, Guoyao
通讯作者:
Hou, Yongqing
作者机构:
[Hou, Yongqing; Wang, Lei; Wu, Guoyao; Yi, Dan] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
[Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.
通讯机构:
[Hou, Yongqing] W
Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
Acetic acid;Intestinal functions;Lipopolysaccharide;N-acetylcysteine;Piglets;Review
期刊:
FRONTIERS IN BIOSCIENCE-LANDMARK
ISSN:
2768-6701
年:
2015
卷:
20
期:
5
页码:
872-891
DOI:
基金类别:
National Basic Research Program of ChinaNational Basic Research Program of China [2012CB126305]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31372319]; Hubei Provincial Research and Development Program [2010BB023]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2013CFA097, 2013CFB325, 2012FFB04805, 2011CDA131]; Hubei Hundred Talent program; Agriculture ad Food Research Initiative Competitive Grants of the USDA National Institute of Food and Agriculture [2014-67015-21770]; Texas AgriLife Research [H-8200]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
The integrity of the intestinal epithelium ensures its normal physiological function. Consequently, damage to the mucosal epithelium can impair the absorption of nutrients, thereby reducing the growth performance and compromising the health of animals. N-acetylcysteine (NAC) is pharmaceutically available either intravenously, orally, or by inhalation for reducing endothelial dysfunction, inflammation, fibrosis, invasion, cartilage erosion, acetaminophen detoxification, and transplant prolongation. NAC is rapidly metabolized by the small intesti...

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