This study was supported by Scientific Research Fund of Hubei Provincial Department of Education (No. B2016081) and Young Scholar Research Grant of Chinese Anesthesiologist Association (No. 21700007).
机构署名：
本校为通讯机构
院系归属：
医学与健康学院
摘要：
Acute respiratory distress syndrome (ARDS) is associated with a mortality of 45%. Our previous research indicated that anti-vascular endothelial growth factor (VEGF) could maintain the normal structure and function of the respiratory barrier. However, systemic application of VEGF antagonists would lead to animal death. This study attempts to study the targeted drug delivery for ARDS. In this study, we used soluble fms-like tyrosine kinase-1 (sFlt)-targeted ultrasound microbubbles to antagonize the effect of VEGF on lung tissue. Ninety male BALB...
