Effect of the A-Type Linkage on the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins

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成果类型：

期刊论文

作者：

Li, Shuyi*;Liu, Yang;Liu, Gang*;He, Jingren;Qin, Xinguang;...

通讯作者：

Li, Shuyi;Liu, Gang

作者机构：

[Liu, Gang; Hu, Zhongze; Li, Shuyi; Qin, Xinguang; Lamikanra, Olusola; Liu, Yang; Li, SY; He, Jingren] Wuhan Polytechn Univ, Coll Food Sci & Engn, Wuhan 430023, Hunan, Peoples R China.

[Yang, Haochen] Tianjin Univ, Coll Chem Engn, Tianjin 300072, Peoples R China.

通讯机构：

[Li, SY; Liu, G] W

Wuhan Polytechn Univ, Coll Food Sci & Engn, Wuhan 430023, Hunan, Peoples R China.

语种：

英文

关键词：

Biochemistry;Dimers;Metabolism;Metabolites;Oligomers;Pharmacokinetics;Physiology;Rating;Rats;Degree of polymerization;Gastrointestinal systems;Intestinal metabolisms;Metabolite profiles;Microbial metabolism;Procyanidin oligomers;Quantitative structure activity relationship;Sprague-Dawley rats;Flavonoids;biflavonoid;catechin;plant extract;proanthocyanidin;procyanidin;animal;chemical structure;chemistry;fruit;intestine;lychee;male;metabolism;polymerization;rat;Sprague Dawley rat;Animals;Biflavonoids;Catechin;Fruit;Intestines;Litchi;Male;Molecular Structure;Plant Extracts;Polymerization;Proanthocyanidins;Rats;Rats, Sprague-Dawley

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2017

卷：

期：

页码：

1893-1899

DOI：

10.1021/acs.jafc.7b00017

基金类别：

National Natural Science Foundation for Young Scholars of ChinaNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [31501482, 31401640]; Science and Technology Support Program of Hubei Province, China [2015BBA167]; Hubei Province "One Hundred Talent Program"

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

The bioavailability of A-type procyanidins in vivo has been rarely investigated; as such, this study discusses the effect of A-type linkage and degree of polymerization on the metabolism of procyanidins extracted from litchi pericarp (LPOPC). Sprague-Dawley rats were gavaged with (−)-epicatechin (EC) and LPOPC and sacrificed at different time points after ingestion. A-type linkage procyanidin oligomers inhibited the absorption of EC. Analysis of urinary contents from rats administered with EC, A-type procyanidin dimer (A-2), and A-type procyan...

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Effect of the A-Type Linkage on the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins

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