[陈新] College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China
[张晓琳; 李能威; 韩伟; 郭伟群] Academy of State Administration of Grain, Beijing 100037, China
[杨世红] College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China, Academy of State Administration of Grain, Beijing 100037, China
通讯机构：
[Zhang, X.-L.] A
Academy of State Administration of Grain, Beijing 100037, China
Objective Exploring an effective method of increasing doramectin productivity of Streptomyces avermitilis with the research of feeding of doramectin precursors. Methods The effects of different precursors on the biosynthesis of doramectin, the optimum concentration and feeding time of the effective precursor were studied. Result Sodium propionate was the optimal precursor for doramectin biosynthesis. By feeding of 0.1% sodium propionate into the fermentation broth at the 96th hour of cultivation, the doramectin production was 139.89μg/mL,38.2%...
