期刊论文

Cheng, QZ;Ding, H

英文

Epilepsy Research

0920-1211

2024

201

107321

10.1016/j.eplepsyres.2024.107321

This work was supported by the Scientific Research Project of Wuhan Polytechnic University (Grant No. 2023Y66). CRediT authorship contribution statement Cheng Yahong: Methodology, Software, Validation, Writing – original draft. Zhang Yiyuan: Data curation, Investigation. Huang Puxin: Data curation, Resources. Cheng Qingzhou: acquisition, Supervision. Ding Hong: Conceptualization, Project administration, Supervision.

本校为第一且通讯机构

Epilepsy represents a prevalent neurological disorder in the population, and the existing antiepileptic drugs (AEDs) often fail to adequately control seizures. Inflammation is recognized as a pivotal factor in the pathophysiology of epilepsy. Luteolin, a natural flavonoid extract, possesses anti-inflammatory properties and exhibits promising neuroprotective activity. Nevertheless, the precise molecular mechanisms underlying the antiepileptic effects of luteolin remain elusive. In this study, we established a rat model of epilepsy using pentylenetetrazole (PTZ) to induce seizures. A series of b...