期刊论文

Xu, Chengzhi;Wang, Haibo

英文

Chemical Papers

2585-7290

2022

76

3

1377-1384

10.1007/s11696-021-01935-x

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21676208, 21706201, 22178277]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2018CFA030, 2019CFB252]; Application Foundation Frontier Project of Wuhan Science and Technology Bureau [2019020701011478]

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Fiber-like aggregation is characteristic of the collagen molecule and appears in all descriptions of collagen from its molecular behavior to the creation of novel materials. In this work, we developed a novel assay for monitoring collagen’s fiber-like aggregation using gold nanoparticles (GNPs) as probes. This strategy relies upon the distance-dependent optical properties of GNPs. In the absence of fiber-like aggregation, the GNPs were stabilized by collagen and did not aggregate in the presence of high salt. After fiber-like aggregation, the ...