Design and Synthesis of 4(1H)-quinolone Derivatives as Autophagy Inducing Agents by Targeting ATG5 Protein

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jia, Yifan;Yu, Difei;Huang, Qiuhua;Zhang, Xiaodong;Qiu, Liqin;...

通讯作者：

Liu, Wenbin;Du, Runlei;Cao, Rihui

作者机构：

[Jia, Yifan] Wuhan Univ, Dept Pain Management, Renmin Hosp, Wuhan 430060, Peoples R China.

[Liu, Wenbin] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Peoples R China.

[Zhang, Xiaodong; Yu, Difei; Du, Runlei] Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Peoples R China.

[Huang, Qiuhua; Cao, Rihui; Qiu, Liqin] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China.

通讯机构：

[Liu, Wenbin; Du, Runlei] W

[Cao, Rihui] S

Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Peoples R China.

Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Peoples R China.

Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China.

语种：

英文

关键词：

Synthesis;quinolone;antiproliferative;autophagy;mechanism of action;ATG5 protein.

期刊：

LETTERS IN DRUG DESIGN & DISCOVERY

ISSN：

1570-1808

年：

2020

卷：

期：

页码：

884-890

DOI：

10.2174/1570180816666191122113045

基金类别：

Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [S2013010012138, 2016A030313349]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872271, 31501148, 81402994]

机构署名：

本校为通讯机构

院系归属：

医学与健康学院

摘要：

Background: Quinolines have been characterized as a class of potential antitumor agents, and a large number of natural and synthetic quinolines acting as antitumor agents were reported. Methods: A series of 7-chloro-4(1H)-quinolone derivatives were synthesized. The antiproliferative effect of these compounds was evaluated by MTT assay against five human tumor cell lines. The mechanism of action of the selected compound 7h was also investigated. Results and Discussion: Most of the compounds had more potent antiproliferative activities than the lead compound 7-chloro-4(1H)-quinolone 6b. Compound...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Design and Synthesis of 4(1H)-quinolone Derivatives as Autophagy Inducing Agents by Targeting ATG5 Protein

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问