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The protective effects of Esculentoside A through AMPK in the triple transgenic mouse model of Alzheimer's disease

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成果类型：

期刊论文

作者：

He, Zhijun;Zhang, Huajie;Li, Xiaoqian;Tu, Sixin;Wang, Zi;...

通讯作者：

Qiong Liu

作者机构：

[Li, Xiaoqian; Wang, Zi; Du, Xiubo; Zhang, Huajie; Han, Shuangxue; He, Zhijun; Li, Nan; Liu, Qiong; Tu, Sixin; Shen, Liming] Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen Key Lab Marine Biotechnol & Ecol, Shenzhen 518055, Guangdong, Peoples R China.

[He, Zhijun] Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pro, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

[Li, Nan; Liu, Qiong] Shenzhen Bay Lab, Shenzhen 518055, Peoples R China.

[Du, Xiubo] Shenzhen Hong Kong Inst Brain Sci, Shenzhen Fundamental Res Inst, Shenzhen 518055, Peoples R China.

通讯机构：

[Qiong Liu] S

Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518055, China<&wdkj&>Shenzhen Bay Laboratory, Shenzhen 518055, China

语种：

英文

关键词：

Alzheimer's disease (AD);Esculentoside A (EsA);Isobaric tags for relative and absolute;quantitation (iTRAQ);AMP-activated protein kinase (AMPK);Microtubule-associated protein tau (Tau)

期刊：

Phytomedicine

ISSN：

0944-7113

年：

2023

卷：

109

页码：

154555

DOI：

10.1016/j.phymed.2022.154555

基金类别：

CRediT authorship contribution statement Zhijun He: Conceptualization, Visualization, Investigation, Data curation, Writing – review & editing. Huajie Zhang: Formal analysis, Visualization. Xiaoqian Li: Investigation, Data curation. Sixin Tu: Investigation. Zi Wang: Investigation. Shuangxue Han: Investigation. Xiubo Du: Supervision, Validation. Liming Shen: Methodology. Nan Li: Writing – review & editing, Validation. Qiong Liu: acquisition, Project administration, Resources.

机构署名：

本校为其他机构

院系归属：

硒科学与工程现代产业学院

摘要：

Background: Neurofibrillary tangles comprising hyperphosphorylated tau are vital factors associated with the pathogenesis of Alzheimer's disease (AD). The elimination or reduction of hyperphosphorylated and abnormally aggregated tau is a valuable measure in AD therapy. Esculentoside A (EsA), isolated from Phytolacca esculenta, exhibits pharmacotherapeutic efficacy in mice with amyloid beta-induced AD. However, whether EsA affects tau pathology and its specific mechanism of action in AD mice remains unclear. Purpose: To investigate the roles and mechanisms of EsA in cognitive decline and tau pa...

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The protective effects of Esculentoside A through AMPK in the triple transgenic mouse model of Alzheimer's disease

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