Xylooligosaccharide attenuates lipopolysaccharide-induced intestinal injury in piglets via suppressing inflammation and modulating cecal microbial communities
[Yu, Cheng] South Cent Univ Nationalities, Coll Life Sci, Wuhan 430023, Peoples R China.
通讯机构：
[Yulan Liu] H
Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan, 430023, China
funded by the Projects of Innovative Research Groups of the Natural Science Foundation of Hubei Province （grant number 2019CFA015）； National Natural Science Foundation of China （grant number 31802070 and 31772615）； Wuhan Science and Technology Bureau （grant number 2018020401011304）；
机构署名：
本校为第一机构
院系归属：
动物科学与营养工程学院
摘要：
Xylooligosaccharide（XOS） has been considered to be an effective prebiotic,but its exact mechanisms remain unknown.This research was conducted to evaluate the effects of XOS on pig intestinal bacterial community and mucosal barrier using a lipopolysaccharide（LPS）-caused gut damage model.Twentyfour weaned pigs were assigned to 4 treatments in a 2 × 2 factorial design involving diet（with or without XOS） and immunological challenge（saline or LPS）.After 21 d of feeding 0% or 0.02% commercial XOS product,piglets were treated with saline or L...
