Environmental cadmium exposure induces alterations in the urinary metabolic profile of pregnant women

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成果类型：

期刊论文

作者：

Li, Han;Huang, Kai;Jin, Shuna;Peng, Yang;Liu, Wenyu;...

通讯作者：

Xu, Shunqing;Lu, Shi

作者机构：

[Xia, Wei; Li, Yuanyuan; Li, Han; Xu, Shunqing; Wang, Mu; Peng, Yang; Jin, Shuna; Liu, Wenyu] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan, Hubei, Peoples R China.

[Xia, Wei; Li, Yuanyuan; Li, Han; Xu, Shunqing; Wang, Mu; Peng, Yang; Jin, Shuna; Liu, Wenyu] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect,State Key Lab Environm Hl, Wuhan, Hubei, Peoples R China.

[Li, Han; Peng, Yang] Guangxi Med Univ, Sch Publ Hlth, Nanning, Peoples R China.

[Huang, Kai] Chenzhou Ctr Dis Control & Prevent, Chenzhou, Peoples R China.

[Zhang, Hongling] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan, Hubei, Peoples R China.

通讯机构：

[Xu, Shunqing; Lu, Shi] H

Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan, Hubei, Peoples R China.

Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect,State Key Lab Environm Hl, Wuhan, Hubei, Peoples R China.

Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Obstet & Gynecol, Union Hosp, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

*Biomarkers;*Cadmium exposure;*Early pregnancy;*Metabolomics

期刊：

International Journal of Hygiene and Environmental Health

ISSN：

1438-4639

年：

2019

卷：

222

期：

页码：

556-562

DOI：

10.1016/j.ijheh.2019.02.007

基金类别：

National Key Research and Development Plan of China [2016YFC0206203]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M622458]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91743103, 91643207]; Fundamental Research Funds for the Central Universities HUSTFundamental Research Funds for the Central Universities [2016YXZD043, 2015ZDTD047, 2018KFYXMPT00]

机构署名：

本校为其他机构

院系归属：

医学与健康学院

摘要：

Cadmium (Cd) is a well-recognized, hazardous toxic heavy metal, and the adverse effects of high-level Cd exposure on human health have been well documented. However, little is known about the health effects of low-level environmental Cd exposure on pregnant women. The objective of this study was to assess urinary metabolic alterations in pregnant women exposed to environmental Cd, and to identify informative biomarkers. Urine samples from 246 pregnant women in the first trimester of pregnancy were collected, and urinary Cd concentrations were quantified using inductively coupled plasma mass sp...

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Environmental cadmium exposure induces alterations in the urinary metabolic profile of pregnant women

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