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Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells

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成果类型:
期刊论文
作者:
Bai, Ding-Ping;Zhang, Xi-Feng;Zhang, Guo-Liang;Huang, Yi-Fan;Gurunathan, Sangiliyandi*
通讯作者:
Gurunathan, Sangiliyandi
作者机构:
[Bai, Ding-Ping; Huang, Yi-Fan] Fujian Agr & Forestry Univ, Fujian Key Lab Tradit Chinese Vet Med & Anim Hlth, Fuzhou, Fujian, Peoples R China.
[Zhang, Xi-Feng] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.
[Zhang, Guo-Liang] Dong E E Jiao Co Ltd, Liaocheng, Shandong, Peoples R China.
[Zhang, Guo-Liang] Natl Engn Res Ctr Gelatin Based Tradit Chinese Me, Liaocheng, Shandong, Peoples R China.
[Gurunathan, Sangiliyandi] Konkuk Univ, Dept Stem Cell & Regenerat Biotechnol, Seoul 143701, South Korea.
通讯机构:
[Gurunathan, Sangiliyandi] K
Konkuk Univ, Dept Stem Cell & Regenerat Biotechnol, Seoul 143701, South Korea.
语种:
英文
关键词:
zinc oxide nanoparticles;human ovarian cancer cells SKOV3;mitochondrial membrane potential;apoptosis;DNA fragmentation;autophagy
期刊:
INTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN:
1178-2013
年:
2017
卷:
12
页码:
6521-6535
基金类别:
KU-Research Professor Program of Konkuk University; Science and Technology Research Program of the Department of Education of Hubei Province, People's Republic of China [D20151701]
机构署名:
本校为其他机构
院系归属:
生命科学与技术学院
摘要:
Background: Zinc oxide nanoparticles (ZnO NPs) are frequently used in industrial products such as paint, surface coating, and cosmetics, and recently, they have been explored in biologic and biomedical applications. Therefore, this study was undertaken to investigate the effect of ZnO NPs on cytotoxicity, apoptosis, and autophagy in human ovarian cancer cells (SKOV3). Methods: ZnO NPs with a crystalline size of 20 nm were characterized with various analytical techniques, including ultraviolet-visible spectroscopy, X-ray diffraction, transmissio...

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