Preparation of combined colchicine with loxoprofen sodium loaded in dissolvable microneedles and its anti-gouty arthritis effect

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成果类型：

期刊论文

作者：

Liu, Mingxue;Yang, Huimin;Wang, Yu;Fu, Wanting;Dong, Changle;...

通讯作者：

Xu, LY

作者机构：

[Wang, Yu; Dong, Changle; Fu, Wanting; Xu, Lingyun; Han, Di; Liu, Mingxue; Sun, Shuping; Zou, Yifeng; Yang, Huimin; Ye, Aoqi] Wuhan Polytech Univ, Sch Life Sci & Technol, Xuefu South Rd 68,Changqing Garden, Wuhan 430023, Peoples R China.

[Zhang, Hongling] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan 430023, Peoples R China.

[Qiu, Yinsheng] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Xu, LY ] W

Wuhan Polytech Univ, Sch Life Sci & Technol, Xuefu South Rd 68,Changqing Garden, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Gouty arthritis;Colchicine;Loxoprofen sodium;Dissolvable microneedles;Transdermal delivery

期刊：

Journal of Drug Delivery Science and Technology

ISSN：

1773-2247

年：

2025

卷：

104

页码：

106471

DOI：

10.1016/j.jddst.2024.106471

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

医学与健康学院

摘要：

Both colchicine (Col) and loxoprofen sodium (LS) are first-line drugs for gouty arthritis (GA). Dissolvable microneedles (DMNs) represent an innovative transdermal drug delivery system (TDDS) that maximizes the therapeutic effect of drugs. In this paper, a novel TDDS of combined Col with LS loaded in DMNs (Col-LS-DMNS) was prepared to treat GA. To assess the synergistic effects of Col and LS, cell viability assays were conducted using monosodium urate (MSU)-induced HaCaT cells. The optimization of the Col-LS-DMNs formulation was carried out thr...

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Preparation of combined colchicine with loxoprofen sodium loaded in dissolvable microneedles and its anti-gouty arthritis effect

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