期刊论文

中文

中国饲料

1004-3314

2018

9

47-51

10.15906/j.cnki.cn11-2975/s.20180910

湖北省教育厅优秀中青年科技创新团队项目（T201508）；

本校为其他机构

为研究甘氨酸(Gly)对脂多糖(LPS)刺激引起的断奶仔猪肠道能量代谢紊乱的影响,试验选用24头体重为(7.17±0.41)kg的健康断奶仔猪[(21±1)d],分为4个处理组,分别为对照组、LPS组、1.0% Gly组和2.0% Gly组.试验第28天,LPS组、1.0% Gly组和2.0% Gly组猪注射100 μg/kg BW 的LPS,对照组注射相同剂量的生理盐水,4 h后屠宰,采集小肠样品待测.结果表明:Gly提高了肠道腺苷酸含量和三羧酸循环关键酶活性,影响了能量代谢相关基因过氧化物酶体增殖物激活受体γ辅激活因子1α和沉默信号调控因子1 mRNA表达.以上结果表明,Gly可以缓解LPS刺激导致的肠道能量代谢紊乱.

The experiment was conducted to investigate the effects of glycine（Gly） on intestinal energy metabolism disorder caused by lipopolysaccharide（LPS） challenge.Twenty-four healthy piglets [（21 ±1）d,（7.17±0.41）kg] were divided into 4 treatments（control group,LPS group,1.0% Gly group and 2.0% Gly group）.On 28 d,the piglets in the LPS group,1.0% Gly group and 2.0% Gly group were injected with 100 μg/kg BW LPS,and the piglets in the control group were injected with the same volume of Na Cl solution.All piglets were slaughtered at 4 h afte...