Generation of epidermal growth factor and green fluorescent protein coexpressing Lactobacillus acidophilus and its effect on intestinal histology improvement in mature LPS-challenged mice

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成果类型：

期刊论文

作者：

Lv, Yang;Kang, Ping;Zhang, Lin;Li, Xueni;Wang, Lei;...

通讯作者：

Wu, Tao

作者机构：

[Wu, Tao; Lv, Yang; Kang, Ping; Hou, Yongqing; Wang, Lei; Li, Xueni; Zhao, Di; Ding, Binying; Yi, Dan; Chen, Hongbo] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan 430023, Hubei, Peoples R China.

[Zhang, Lin] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China.

[Zhang, Lin] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430070, Hubei, Peoples R China.

通讯机构：

[Wu, Tao] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

Epidermal growth factor;Intestinal histology;LPS-challenged mice;Lactobacillus acidophilus

期刊：

THAI JOURNAL OF VETERINARY MEDICINE

ISSN：

0125-6491

年：

2018

卷：

期：

页码：

147-156

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31302089]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2012FFBO4804]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

The aim of the present study was to construct a recombinant strain by using the probiotics Lactobacillus acidophilus expressing the epidermal growth factor (EGF), which can improve intestinal morphology, and to test its effect on the intestinal histology in LPS (lipopolysaccharide)-challenged mice. The EGF gene was cloned into the shuttle vector pSET4s and then transformed into the L. acidophilus MG6243 strain by electroporation. Two recombinant strains were confirmed by SDS-PAGE and named ΔMG6243-1 and ΔMG6243-2. Sixty mice were randomly ass...

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Generation of epidermal growth factor and green fluorescent protein coexpressing Lactobacillus acidophilus and its effect on intestinal histology improvement in mature LPS-challenged mice

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