Accurate segmentation of the optic disc (OD) depicted on color fundus images may aid in the early detection and quantitative diagnosis of retinal diseases, such as glaucoma and optic atrophy. In this study, we proposed a coarse-to-fine deep learning framework on the basis of a classical convolutional neural network (CNN), known as the U-net model, to accurately identify the optic disc. This network was trained separately on color fundus images and their grayscale vessel density maps, leading to two different segmentation results from the entire...
