Endothelial versus Metabolic Insulin Resistance, A Descriptive Review

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成果类型：

期刊论文

作者：

Chen, Xiaohui;Yao, Huajie;Lai, Jiaqi;Chen, Yanmei;Li, Xiaodong;...

通讯作者：

He, FZ

作者机构：

[Chen, Yanmei; Yao, Huajie; Chen, Xiaohui; He, Fazhong; Lai, Jiaqi; Li, Xiaodong; Li, Shanshan] Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Hosp, Dept Qual Control, Zhuhai, Peoples R China.

[Chen, Xiaohui; Lai, Jiaqi] Jinan Univ, Coll Pharm, Guangzhou, Peoples R China.

[Yao, Huajie] Wuhan Polytech Univ, Coll Life Sci & Technol, Dept Pharm, Wuhan, Peoples R China.

[Li, Ling] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Pharm, Zhuhai, Peoples R China.

通讯机构：

[He, FZ ] J

Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Hosp, Dept Qual Control, Zhuhai, Peoples R China.

语种：

英文

关键词：

diabetes-related cardiovascular complications;endothelial dysfunction;endothelial insulin resistance;metabolic insulin resistance;oxidative stress;therapies.

期刊：

Current Diabetes Reviews

ISSN：

1573-3998

年：

2025

卷：

期：

页码：

94-105

DOI：

10.2174/0115733998288601240327065724

基金类别：

National Science Foundation of China [81903715]; Zhuhai People's Hospital's Xiangshan talent project [2020XSYC-01]; Natural Science Foundation of Guangdong Province [2022A1515012648]; Hospital Pharmacy Research Foundation of Guangdong Province [2022A01]; Key project of Evaluation and Research Fund of off-label drug use in Oncology by Pharmaceutical Society of Guangdong Province [2023ZLCS13]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Cardiovascular complications are a primary focus in the clinical management of type 2 diabetes, as they are the leading causes of disability and mortality in individuals with diabetes. Insulin resistance and endothelial dysfunction commonly coexist in diabetic patients. An increasing body of research indicates a reciprocal and interconnected association between endothelial function and insulin resistance. Insulin resistance can manifest in two distinct forms: endothelial and metabolic, with the former predominantly affecting vascular endothelial cells and the latter primarily impacting periphe...

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