Cholinesterases and Engineered Mutants for the Detection of Organophosphorus Pesticide Residues

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成果类型：

期刊论文

作者：

Xu, Yu-Ling;Li, Feng-Ye;Ndikuryayo, Ferdinand;Yang, Wen-Chao*;Wang, Hong-Mei*

通讯作者：

Yang, Wen-Chao;Wang, Hong-Mei

作者机构：

[Xu, Yu-Ling] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Hubei, Peoples R China.

[Ndikuryayo, Ferdinand; Yang, Wen-Chao; Li, Feng-Ye] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.

[Ndikuryayo, Ferdinand; Yang, Wen-Chao; Li, Feng-Ye] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China.

[Ndikuryayo, Ferdinand; Yang, Wen-Chao; Li, Feng-Ye] Cent China Normal Univ, Chem Biol Ctr, Coll Chem, Wuhan 430079, Hubei, Peoples R China.

[Wang, Hong-Mei] Hubei Univ Med, Sch Pharm, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China.

通讯机构：

[Yang, Wen-Chao] C

[Wang, Hong-Mei] H

Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.

Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China.

Cent China Normal Univ, Chem Biol Ctr, Coll Chem, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

关键词：

cholinesterase;mutant;organophosphorus pesticides;sensor

期刊：

Sensors

ISSN：

1424-3210

年：

2018

卷：

期：

页码：

4281

DOI：

10.3390/s18124281

基金类别：

National Key Research and Development Program of China [2017YFA0505200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672079]; Hubei Province Natural Science FoundationNatural Science Foundation of Hubei Province [2018CFA072]; self-determined research funds of Central China Normal University from the colleges' basic research and operation of MOE" [CCNU18ZDPY01, CCNU18TS007]

机构署名：

本校为第一机构

院系归属：

化学与环境工程学院

摘要：

Nowadays, pesticide residues constitute an increasing public health concern. Cholinesterases, acetylcholinesterase, and butyrylcholinesterase, are reported to be involved in detoxification processes owing to their capability of scavenging organophosphates and carbamates. Thus, these enzymes are targeted for the discovery of sensors aiming at detecting pesticide residues. In recent years, cholinesterase-based biosensors have attracted more and more attention in the detection of pesticides. Herein, this review describes the recent progress on the engineering of cholinesterases and the developmen...

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Cholinesterases and Engineered Mutants for the Detection of Organophosphorus Pesticide Residues

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