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Dietary DHA/EPA ratio changes fatty acid composition and attenuates diet-induced accumulation of lipid in the liver of ApoE−/− mice

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成果类型:
期刊论文
作者:
Liu, Liang;Hu, Qinling;Wu, Huihui;Wang, Xiujing;Gao, Chao;...
通讯作者:
Gong, Zhiyong
作者机构:
[Wang, Xiujing; Wu, Huihui; Gong, Zhiyong; Liu, Liang; Hu, Qinling] Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.
[Wang, Xiujing; Wu, Huihui; Gong, Zhiyong; Liu, Liang; Hu, Qinling] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China.
[Gong, Zhiyong; Liu, Liang] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.
[Gao, Chao] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing 100050, Peoples R China.
[Chen, Guoxun] Univ Tennessee, Dept Nutr, Knoxville, TN 37996 USA.
通讯机构:
[Gong, Zhiyong] M
[Gong, Zhiyong] W
Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.
Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China.
Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
关键词:
Alkalinity;Amino acids;Body fluids;Cholesterol;Diseases;Gene expression;Mammals;Metabolism;Phosphatases;Physiology;Plants (botany);Polyunsaturated fatty acids;Alanine aminotransferase;Aspartate aminotransferase;Biochemical parameters;Fatty acid composition;Inflammatory response;Low density lipoproteins;Non-alcoholic fatty liver disease;Polyunsaturated fatty acids (PUFAs);Monounsaturated fatty acids;ABC transporter A1;ABC transporter G1;adenylate kinase;adiponectin;alanine aminotransferase;alkaline phosphatase;aspartate aminotransferase;CD36 antigen;cholesterol;cholesterol acyltransferase;cytokine;docosahexaenoic acid;fatty acid;glutathione;icosapentaenoic acid;low density lipoprotein;low density lipoprotein cholesterol;lysosomal acid lipase;macrophage scavenger receptor 1;malonaldehyde;messenger RNA;monounsaturated fatty acid;omega 3 fatty acid;omega 6 fatty acid;oxidized low density lipoprotein receptor 1;peroxisome proliferator activated receptor alpha;sterol regulatory element binding protein 1c;superoxide dismutase;triacylglycerol;unclassified drug;unindexed drug;docosahexaenoic acid;fatty acid;icosapentaenoic acid;alanine aminotransferase blood level;alkaline phosphatase blood level;animal experiment;animal model;animal tissue;Article;aspartate aminotransferase blood level;biochemical analysis;cholesterol blood level;controlled study;gene expression;lipid composition;lipid diet;lipid homeostasis;lipid liver level;lipid metabolism;lipid storage;liver injury;male;mouse;nonalcoholic fatty liver;nonhuman;oxidative stress;triacylglycerol blood level;animal;apolipoprotein E knockout mouse;C57BL mouse;lipid diet;liver;metabolism;nonalcoholic fatty liver;pathology;Alkalinity;Amino Acids;Diseases;Mammals;Metabolism;Sterols;Animals;Diet, High-Fat;Docosahexaenoic Acids;Eicosapentaenoic Acid;Fatty Acids;Liver;Male;Mice;Mice, Inbred C57BL;Mice, Knockout, ApoE;Non-alcoholic Fatty Liver Disease
期刊:
Oxidative Medicine and Cellular Longevity
ISSN:
1942-0900
年:
2018
卷:
2018
页码:
6256802
基金类别:
This work was supported by the National Key Research and Development Program of China (no. 2017YFC1600500), the National High-Tech Research and Development Projects (no. 2010AA023003), the National Natural Science Foundation of China (no. 31201351), the Young Elite Scientists Sponsorship Program by CAST (China Association for Science and Technology) (no. YESS20160164), and the 2015 Chinese Nutrition Society DSM Research Fund. We would like to thank LetPub for English language editing.
机构署名:
本校为通讯机构
院系归属:
食品科学与工程学院
摘要:
Diets containing various docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) ratios protect against liver damage in mice fed with a high-fat diet (HFD). However, it is unclear whether these beneficial roles of DHA and EPA are associated with alterations of fatty acid (FA) composition in the liver. This study evaluated the positive impacts of n-6/n-3 polyunsaturated fatty acids (PUFAs) containing different DHA/EPA ratios on HFD-induced liver disease and alterations of the hepatic FA composition. ApoE−/− mice were fed with HFDs with various ...

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