Activation of the NF-κ B and MAPK Signaling Pathways Contributes to the Inflammatory Responses, but Not Cell Injury, in IPEC-1 Cells Challenged with Hydrogen Peroxide
Project of Innovative Research Groups of the Natural Science Foundation of Hubei Province [2019CFA015]; Project of the Hubei Provincial Department of Education [T201508]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
Oxidative stress can lead to intestinal cell injury as well as the induction of inflammation. It is not clear whether inflammation is an important factor leading to cell injury caused by oxidative stress. The purpose of this study was to investigate the role of inflammation in intestinal injury caused by hydrogen peroxide (H2O2). Our results revealed that H2O2 stimulation significantly decreased the viability of intestinal porcine epithelial cells (IPEC-1), increased lactate dehydrogenase (LDH) activity, and disrupted the distribution of the ti...